Effect of DGAT knockdown on gene expression in A498 xenograft tumors

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GSE117774

Homo sapiens

8 Downloadable Samples

Affymetrix Human Transcriptome Array 2.0 (hta20)

Submitter Supplied Information

Description

The metabolic enzyme diglyceride acyltransferase (DGAT) is responsible for the synthesis of triglycerides. Loss of its expression may sensitize cells to conditions of nutrient and oxygen that are commonly present in tumors. This study is designed to identify stress response pathways that may be induced following the shRNA-mediated knockdown of the two genes coding for the DGAT enzymes.

PubMed ID

30184495

Publication Title

Triglycerides Promote Lipid Homeostasis during Hypoxic Stress by Balancing Fatty Acid Saturation.

Total Samples

Submitter’s Institution

University of Pennsylvania

Authors

Ackerman D, Tumanov S, Qiu B, Michalopoulou E, Spata M, Azzam A, Xie H, Simon MC, Kamphorst JJ

Source Repository

Gene Expression Omnibus (GEO)

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