TRE-Htt-N853 Huntington's Disease in vitro model

GSE12481

Rattus norvegicus

12 Downloadable Samples

Affymetrix Rat Genome 230 2.0 Array (rat2302)

Submitter Supplied Information

Description

Primary neuron model of Huntington's Disease. 2 treatment groups: A) Infected 4 weeks prior with TRE-Htt-N853-18Q-expressing recombinant lentivirus, B) Infected 4 weeks prior with TRE-Htt-N853-82Q-expressing recombinant lentivirus

PubMed ID

18815258

Publication Title

Dysregulation of gene expression in primary neuron models of Huntington's disease shows that polyglutamine-related effects on the striatal transcriptome may not be dependent on brain circuitry.

Total Samples

Submitter’s Institution

NIH

Authors

Runne H, Régulier E, Kuhn A, Zala D, Gokce O, Perrin V, Sick B, Aebischer P, Déglon N, Luthi-Carter R

Source Repository

Gene Expression Omnibus (GEO)

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