Inter-strain Heterogeneity in Responses to TCDD

GSE31411

Rattus norvegicus

56 Downloadable Samples

Affymetrix Rat Genome 230 2.0 Array (rat2302), Affymetrix Rat Expression 230A Array (rae230a)

Submitter Supplied Information

Description

We profiled hepatic transcriptional responses of 6 strains of rats with varying sensitivity to a dioxin, TCDD, at 19 hours following exposure. The resistant rats exhibited significantly reduced transcriptional responses in comparison to the sensitive strains. We hypothesize that genes which show differential changes between the resistant and sensitive rats may potentially explain sensitivity.

PubMed ID

22342509

Publication Title

Inter-strain heterogeneity in rat hepatic transcriptomic responses to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).

Total Samples

Submitter’s Institution

Ontario Institute for Cancer Research

Authors

Yao CQ, Prokopec SD, Watson JD, Pang R, P'ng C, Chong LC, Harding NJ, Pohjanvirta R, Okey AB, Boutros PC

Source Repository

Gene Expression Omnibus (GEO)

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