Epigenome profiling of repressive histone modifications, DNA methylation and gene expression in normal and malignant urothelial cells

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GSE31864

Homo sapiens

3 Downloadable Samples

Affymetrix Human Genome U133 Plus 2.0 Array (hgu133plus2)

Submitter Supplied Information

Description

To gain a more depth knowledge of repressive epigenetic gene regulation in UCC, we have profiled H3K9m3 and H3K27m3 in normal and malignant urothelial cells. We matched these profiles to those 5-methylcytosine and gene expression. We hypothesized that differences represent pro-carcinogenic events within the urothelium.

PubMed ID

22412920

Publication Title

Integrated epigenome profiling of repressive histone modifications, DNA methylation and gene expression in normal and malignant urothelial cells.

Total Samples

Submitter’s Institution

The University of Sheffield

Authors

Dudziec E, Gogol-Döring A, Cookson V, Chen W, Catto J

Source Repository

Gene Expression Omnibus (GEO)

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