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Accession IconGSE32962

In vitro prednisolone resistance signature in MLL-rearranged infant ALL

Organism Icon Homo sapiens
Sample Icon 41 Downloadable Samples
Technology Badge Icon Affymetrix Human Genome U133 Plus 2.0 Array (hgu133plus2)

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Description
Acute Lymphoblastic Leukemia (ALL) in infants (<1 year of age) is characterized by a high incidence of MLL translocations which is associated with a poor prognosis. Contributing to this poor prognosis is cellular drug resistance, especially to glucocorticoids like prednisolone. Although in vitro prednisolone resistance mechanisms have been proposed in pediatric ALL, it has never been studied in MLL-rearranged infant ALL, which are highly resistant to glucocorticoids in vitro and in vivo.
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43
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GSM816426
MLL-rearranged infant ALL in vitro sensitive to prednisolone 10
primary infant all cells at diagnosis (untreated) (>90% blasts)
precursor b-cell acute lymphoblastic leukemia (all)
precursor b-cell acute lymphoblastic leukemia (all)
GSM816421
MLL-rearranged infant ALL in vitro sensitive to prednisolone 5
primary infant all cells at diagnosis (untreated) (>90% blasts)
precursor b-cell acute lymphoblastic leukemia (all)
precursor b-cell acute lymphoblastic leukemia (all)
GSM816410
MLL-rearranged infant ALL in vitro resistant to prednisolone 18
primary infant all cells at diagnosis (untreated) (>90% blasts)
precursor b-cell acute lymphoblastic leukemia (all)
precursor b-cell acute lymphoblastic leukemia (all)
GSM816393
MLL-rearranged infant ALL in vitro resistant to prednisolone 1
primary infant all cells at diagnosis (untreated) (>90% blasts)
precursor b-cell acute lymphoblastic leukemia (all)
precursor b-cell acute lymphoblastic leukemia (all)
GSM816413
MLL-rearranged infant ALL in vitro resistant to prednisolone 21
primary infant all cells at diagnosis (untreated) (>90% blasts)
precursor b-cell acute lymphoblastic leukemia (all)
precursor b-cell acute lymphoblastic leukemia (all)
GSM816409
MLL-rearranged infant ALL in vitro resistant to prednisolone 17
primary infant all cells at diagnosis (untreated) (>90% blasts)
precursor b-cell acute lymphoblastic leukemia (all)
precursor b-cell acute lymphoblastic leukemia (all)
GSM816427
MLL-rearranged infant ALL in vitro sensitive to prednisolone 11
primary infant all cells at diagnosis (untreated) (>90% blasts)
precursor b-cell acute lymphoblastic leukemia (all)
precursor b-cell acute lymphoblastic leukemia (all)
GSM816416
MLL-rearranged infant ALL in vitro resistant to prednisolone 24
primary infant all cells at diagnosis (untreated) (>90% blasts)
precursor b-cell acute lymphoblastic leukemia (all)
precursor b-cell acute lymphoblastic leukemia (all)
GSM816394
MLL-rearranged infant ALL in vitro resistant to prednisolone 2
primary infant all cells at diagnosis (untreated) (>90% blasts)
precursor b-cell acute lymphoblastic leukemia (all)
precursor b-cell acute lymphoblastic leukemia (all)
GSM816435
MLL-rearranged infant ALL in vitro sensitive to prednisolone 19
primary infant all cells at diagnosis (untreated) (>90% blasts)
precursor b-cell acute lymphoblastic leukemia (all)
precursor b-cell acute lymphoblastic leukemia (all)
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