Usp22 depletion in E14 mouse ESCs

GSE42934

Mus musculus

4 Downloadable Samples

Affymetrix Mouse Gene 1.0 ST Array (mogene10st)

Submitter Supplied Information

Description

Mouse ESCs depleted of the epigenetic modifying enzyme Usp22 fail to differentiate properly. Ectopic expresison of Usp22 results in spontaneous differnetiation.

PubMed ID

23760504

Publication Title

The epigenetic modifier ubiquitin-specific protease 22 (USP22) regulates embryonic stem cell differentiation via transcriptional repression of sex-determining region Y-box 2 (SOX2).

Total Samples

Submitter’s Institution

Thomas Jefferson University

Authors

Sussman RT, Stanek TJ, Esteso P, Gearhart JD, Knudsen KE, McMahon SB

Source Repository

Gene Expression Omnibus (GEO)

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