Expression profiling of human adult postmortem brain tissue from subjects with bipolar disorder and healthy controls

Bipolar affective disorder is a severe psychiatric disorder with a strong genetic component but unknown pathophysiology. We used microarray technology (Affymetrix HG-U133A GeneChips) to determine the expression of approximately 22 000 mRNA transcripts in post-mortem brain tissue (dorsolateral prefrontal cortex and orbitofrontal cortex) from patients with bipolar disorder and matched healthy controls.

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Ryan MM, Lockstone HE, Huffaker SJ, Wayland MT, Webster MJ, Bahn S