RNAi off-target analysis in Trp53-/- mouse embryonic fibroblasts transduced with miRNA-based shRNAs targeting Trp53.

GSE59952

Mus musculus

14 Downloadable Samples

Affymetrix Mouse Gene 1.0 ST Array (mogene10st)

Submitter Supplied Information

Description

We analyzed miRNA-based shRNA off-target effects by transducing Trp53-/- MEFs at single- and high-copy with six well-characterized, potent and weak Trp53 shRNAs.

PubMed ID

25100204

Publication Title

Development of siRNA payloads to target KRAS-mutant cancer.

Total Samples

Submitter’s Institution

Mirimus Inc

Authors

Yuan TL, Fellmann C, Lee CS, Ritchie CD, Thapar V, Lee LC, Hsu DJ, Grace D, Carver JO, Zuber J, Luo J, McCormick F, Lowe SW

Source Repository

Gene Expression Omnibus (GEO)

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