Differential gene expression in placentae (E10.5) from adra2bKO and adra2bWT mice

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GSE6909

Mus musculus

6 Downloadable Samples

Affymetrix Mouse Genome 430 2.0 Array (mouse4302)

Submitter Supplied Information

Description

alpha2-adrenoceptors are essential presynaptic regulators of norepinephrine release from sympathetic nerves. Previous studies in mice with targeted deletions in the three alpha2-adrenoceptor genes have indicated that these receptors are essential for embryonic development. In the present study, we searched for the alpha2-adrenoceptor subtype(s) involved in placental development and its molecular mechanism using mice carrying targeted deletions in alpha2-adrenoceptor genes.

PubMed ID

17673674

Publication Title

Upregulation of soluble vascular endothelial growth factor receptor 1 contributes to angiogenesis defects in the placenta of alpha 2B-adrenoceptor deficient mice.

Total Samples

Submitter’s Institution

Institute of Pharmacology

Authors

Muthig V, Gilsbach R, Haubold M, Philipp M, Ivacevic T, Gessler M, Hein L

Source Repository

Gene Expression Omnibus (GEO)

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