Molecular profile of ketamine in comparison to memantine and phencyclidyne and other psychotropic drugs [mouse striatum]

Ketamine has been found to elicit a rapid antidepressant effects in treatment-refractory affective disorders. To indicate the underlying mechanism of action we have performed whole-genome microarray profiling. Moreover, the effects of ketamine were compared to other NMDA receptor antagonists phencyclidine and memantine.

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