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accession-icon GSE22836
Identification of ORS1 target genes using inducible overexpression system
  • organism-icon Arabidopsis thaliana
  • sample-icon 4 Downloadable Samples
  • Technology Badge Icon Affymetrix Arabidopsis ATH1 Genome Array (ath1121501)

Description

The aim was to identify early target genes of the senescence-associated transcription factor: ORS1. For this purpose we used DEX-inducible system and studied the expression profile 5h after treatment using Affymetrix microarray.

Publication Title

ORS1, an H₂O₂-responsive NAC transcription factor, controls senescence in Arabidopsis thaliana.

Sample Metadata Fields

Specimen part

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accession-icon E-MTAB-375
Transcription profiling by array of Arabidopsis after exposure to different temperatures and light levels
  • organism-icon Arabidopsis thaliana
  • sample-icon 175 Downloadable Samples
  • Technology Badge Icon Affymetrix Arabidopsis ATH1 Genome Array (ath1121501)

Description

High-density kinetic analysis of the metabolomic and transcriptomic response of Arabidopsis to temperature and light

Publication Title

High-density kinetic analysis of the metabolomic and transcriptomic response of Arabidopsis to eight environmental conditions.

Sample Metadata Fields

Specimen part, Time

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accession-icon GSE75802
Double-stranded microRNA mimics can induce length- and passenger strand-dependent effects in a cell type-specific manner (RNA 2015)
  • organism-icon Homo sapiens
  • sample-icon 22 Downloadable Samples
  • Technology Badge IconIllumina HumanHT-12 V4.0 expression beadchip

Description

This SuperSeries is composed of the SubSeries listed below.

Publication Title

Double-stranded microRNA mimics can induce length- and passenger strand-dependent effects in a cell type-specific manner.

Sample Metadata Fields

Cell line

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accession-icon GSE75800
Double-stranded microRNA mimics can induce length- and passenger strand-dependent effects in a cell type-specific manner (RNA 2015), Exp 1
  • organism-icon Homo sapiens
  • sample-icon 12 Downloadable Samples
  • Technology Badge IconIllumina HumanHT-12 V4.0 expression beadchip

Description

Experiment 1 - miR-155 and miR-199 Phenotype

Publication Title

Double-stranded microRNA mimics can induce length- and passenger strand-dependent effects in a cell type-specific manner.

Sample Metadata Fields

Cell line

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accession-icon GSE75801
Double-stranded microRNA mimics can induce length- and passenger strand-dependent effects in a cell type-specific manner (RNA 2015), Exp 2
  • organism-icon Homo sapiens
  • sample-icon 10 Downloadable Samples
  • Technology Badge IconIllumina HumanHT-12 V4.0 expression beadchip

Description

Experiment 2 - MiRNA mimics have a length and passenger strand specific effect

Publication Title

Double-stranded microRNA mimics can induce length- and passenger strand-dependent effects in a cell type-specific manner.

Sample Metadata Fields

Cell line

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accession-icon SRP149997
Saccharomyces cerevisiae W303 Raw sequence reads
  • organism-icon Saccharomyces cerevisiae
  • sample-icon 4 Downloadable Samples
  • Technology Badge IconIllumina HiSeq 2000

Description

Transcriptome study of 2 Saccharomyces cerevisiae W303 derivatives, one carrying GFP (control) and one carrying aSyn-GFP

Publication Title

Different 8-hydroxyquinolines protect models of TDP-43 protein, α-synuclein, and polyglutamine proteotoxicity through distinct mechanisms.

Sample Metadata Fields

Specimen part, Disease, Cell line

View Samples
accession-icon E-TABM-566
Transcription profiling by array of Arabidopsis mutant for ron1
  • organism-icon Arabidopsis thaliana
  • sample-icon 6 Downloadable Samples
  • Technology Badge Icon Affymetrix Arabidopsis ATH1 Genome Array (ath1121501)

Description

Transcription profiling of Arabidopsis mutant ron1-1 vs the wild type Ler

Publication Title

The RON1/FRY1/SAL1 gene is required for leaf morphogenesis and venation patterning in Arabidopsis.

Sample Metadata Fields

Specimen part

View Samples
accession-icon GSE54830
Up-regulation of IFN-related genes in BRCA2-/- cells
  • organism-icon Homo sapiens
  • sample-icon 6 Downloadable Samples
  • Technology Badge Icon Affymetrix Human Exon 1.0 ST Array [transcript (gene) version (huex10st)

Description

Microarray-based expression profiling of BRCA2 knockout and isogenic wild type HCT116 human colorectal cancer cells

Publication Title

Up-regulation of the interferon-related genes in BRCA2 knockout epithelial cells.

Sample Metadata Fields

Cell line

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accession-icon GSE4724
Transcriptome analysis of the arginine regulon in E.coli
  • organism-icon Escherichia coli
  • sample-icon 9 Downloadable Samples
  • Technology Badge Icon Affymetrix E. coli Genome 2.0 Array (ecoli2)

Description

Analysis of the response to arginine of the Escherichia coli K-12 transcriptome by microarray hybridization and real-time quantitative PCR provides a first coherent quantitative picture of the ArgR-mediated repression of arginine biosynthesis and uptake genes. Transcriptional repression was shown to be the major control mechanism of the biosynthetic genes, leaving only limited room for additional transcriptional or post-transcriptional regulations. The art genes coding for the specific arginine uptake system are subject to ArgR-mediated repression,

Publication Title

The arginine regulon of Escherichia coli: whole-system transcriptome analysis discovers new genes and provides an integrated view of arginine regulation.

Sample Metadata Fields

No sample metadata fields

View Samples
accession-icon SRP108902
Dihydropyrimidine-thiones and clioquinol synergize to target b-amyloid cellular pathologies through a metal-dependent mechanism
  • organism-icon Saccharomyces cerevisiae
  • sample-icon 8 Downloadable Samples
  • Technology Badge IconIllumina HiSeq 2500

Description

DHPM-thiones rescue Ab-mediated toxicity in a metal-dependent manner that strongly synergizes with clioquinol, a known metal-binding and cytoprotective compound. RNA-seq experiments reveal a modest, yet specific effect on metal-responsive genes that do not change with the inactive control compound. Overall design: Treatment of biological replicates with DMSO, 0.8 uM clioquinol, or 20 uM 10{3,3,1} (DHPM-thione) for ~6 hours prior to harvesting of cells and isolation of total RNA.

Publication Title

Dihydropyrimidine-Thiones and Clioquinol Synergize To Target β-Amyloid Cellular Pathologies through a Metal-Dependent Mechanism.

Sample Metadata Fields

Cell line, Subject

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refine.bio is a repository of uniformly processed and normalized, ready-to-use transcriptome data from publicly available sources. refine.bio is a project of the Childhood Cancer Data Lab (CCDL)

fund-icon Fund the CCDL

Developed by the Childhood Cancer Data Lab

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Cite refine.bio

Casey S. Greene, Dongbo Hu, Richard W. W. Jones, Stephanie Liu, David S. Mejia, Rob Patro, Stephen R. Piccolo, Ariel Rodriguez Romero, Hirak Sarkar, Candace L. Savonen, Jaclyn N. Taroni, William E. Vauclain, Deepashree Venkatesh Prasad, Kurt G. Wheeler. refine.bio: a resource of uniformly processed publicly available gene expression datasets.
URL: https://www.refine.bio

Note that the contributor list is in alphabetical order as we prepare a manuscript for submission.

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