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GSE69862
Gallus gallus
20 Downloadable Samples
Affymetrix Chicken Genome Array (chicken)
Description
To investigate the role of AP-1 in Src-mediated transformation, we undertook a gene profiling study to characterize the transcriptomes of v-Src-transformed CEF expressing either the c-Jun dominant-negative mutant TAM67 or JunD shRNA.
Publication Title
JunD/AP-1 Antagonizes the Induction of DAPK1 To Promote the Survival of v-Src-Transformed Cells.
Sample Metadata Fields
Specimen part
View Samples- Gallus gallus
- 23 Downloadable Samples
- Affymetrix Chicken Genome Array (chicken)
Description
Cell transformation by the Src tyrosine kinase is characterized by extensive changes in gene expression. To describe these changes, investigators have relied extensively on the study of immortalized rodent cell lines or heterogeneous tumor samples that limit the identification of differentially expressed genes or may not represent the full spectrum of biological processes regulated during transformation. In this study, we took advantage of transformation-deficient and temperature sensitive mutants of the Rous sarcoma virus to characterize the patterns of gene expression in two types of primary cells, namely chicken embryo fibroblasts (CEF) and chicken neuro-retinal (CNR) cells.
Publication Title
Cellular processes of v-Src transformation revealed by gene profiling of primary cells--implications for human cancer.
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