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GSE84284
Mus musculus
46 Downloadable Samples
Affymetrix Mouse Gene 1.0 ST Array (mogene10st)
Description
Lymph nodes (LN) are constructed of intricate networks of endothelial and mesenchymal stromal cells. These include the fibroblastic reticular cells (FRC), lymphatic endothelial cells (LEC) and blood endothelial cells (BEC). We performed a comprehensive analysis of LSC responses to skin viral infection and found that LSC subsets responded robustly. Infection induced rapid transcriptional regulation of large numbers of both shared and unique genes in FRC, LEC and BEC to support LN remodeling and the immune response. This transcriptional program was transient, returning to homeostasis within one month of infection. Yet, expanded FRC networks persisted for greater than three months after infection. Our results reveal the complexity of LN stromal cell responses during infection and suggest that LN remodeling to acute infection supports successive immune responses.
Publication Title
Infection Programs Sustained Lymphoid Stromal Cell Responses and Shapes Lymph Node Remodeling upon Secondary Challenge.
Sample Metadata Fields
Sex, Specimen part
View Samples- Mus musculus
- 12 Downloadable Samples
- Affymetrix Mouse Genome 430 2.0 Array (mouse4302)
Description
Mice lacking the function of the PcG protein CBX2 (also known as M33) show defects in gonadal, adrenal, and splenic development. In particular, XY knockout mice develop ovaries but not testes, and the gonads are hypoplastic in both sexes.
Publication Title
Cbx2, a polycomb group gene, is required for Sry gene expression in mice.
Sample Metadata Fields
Specimen part
View Samples