To clarify the downstream signal pathway of EML4-ALK in NSCLC, we performed Affymetrix GeneChip analysis using ALK inhibitor CH5424802-treated NCI-H2228 xenograft tumors, and comprehensively characterized the gene expression regulated by inhibition of activated ALK.
CH5424802, a selective ALK inhibitor capable of blocking the resistant gatekeeper mutant.
Specimen part
View SamplesWe isolated the meristematic and elongation zones of Col-0, upb1-1 mutant and 35S::UPB1-3YFP/upb1-1 plants by micro-dissection and extracted RNA from each section independently.
Transcriptional regulation of ROS controls transition from proliferation to differentiation in the root.
Age, Specimen part
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The bHLH transcription factor POPEYE regulates response to iron deficiency in Arabidopsis roots.
Age, Specimen part
View SamplesTranscriptional profile of whole roots of wild-type and pye-1 mutants exposed to 24 hours -Fe were generated
The bHLH transcription factor POPEYE regulates response to iron deficiency in Arabidopsis roots.
Age, Specimen part
View SamplesPericycle specific transcriptional profiles were generated by FACS (Fluorescence Activated Cell Sorting) of roots that express a pericycle-specific GFP-reporter. FACS cell populations were isolated from roots grown under standard conditions or roots that had been transferred to -Fe media for 24 hours.
The bHLH transcription factor POPEYE regulates response to iron deficiency in Arabidopsis roots.
Age, Specimen part
View SamplesThis SuperSeries is composed of the SubSeries listed below.
Cell identity regulators link development and stress responses in the Arabidopsis root.
Age, Specimen part, Treatment
View SamplesCell-type specific transcriptional profiles were generated by FACS (Fluorescence Activated Cell Sorting) sorting of roots that express cell-type specific GFP-reporters. Five different GFP-reporter lines were used. FACS cell populations were isolated from roots grown under standard pH (pH 5.7) or roots that had been transfered to low pH (pH 4.6) media for 24 hours.
Cell identity regulators link development and stress responses in the Arabidopsis root.
Specimen part
View SamplesTo understand the effect of low pH on developmental stages in the root, we dissected the root into four developmental zones after exposure to low pH and expression profiled each zone.
Cell identity regulators link development and stress responses in the Arabidopsis root.
Age
View SamplesCell-type specific transcriptional profiles were generated by FACS (Fluorescence Activated Cell Sorting) sorting of roots that express cell-type specific GFP-reporters. Five different GFP-reporter lines were used. FACS cell populations were isolated from roots grown under sulfur deficient conditions for 3 hours.
Cell identity regulators link development and stress responses in the Arabidopsis root.
Specimen part
View SamplesWe preformed at time-course of the expression of whole Arabidopsis roots for 3H, 12H, 24H, 48H and 72H after transfer to media lacking sulfur. We combined these data with 13 other datasests and performed a meta-analysis to ask whether a universal stress response exists in Arabidopsis roots.
Cell identity regulators link development and stress responses in the Arabidopsis root.
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