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Homo sapiens
12 Downloadable Samples
NextSeq 500
Description
Bilirubin is a potent antioxidant that reduces inflammation and the accumulation of fat. There have been reports of gene responses to bilirubin, which was mostly attributed to its antioxidant function. These RNA-sequencing studies investigated the impact biliverdin, which is rapidly reduced to bilirubin, has on transcriptome responses in human HepG2 hepatocytes in a PPARa-dependent fashion. This investigation reveals that transcriptome responses from the generation of bilirubin are mostly PPARa-dependent, and its antioxidant function regulates a smaller set of genes.
Publication Title
No associated publication
Sample Metadata Fields
Sex, Age, Specimen part, Disease, Cell line, Treatment, Race
View Samples- Rattus norvegicus
- 12 Downloadable Samples
- Illumina HiSeq 2500
Description
Sympathetic hyperactivity can result from cell-autonomous changes in neurons that innervate cardiovascular target tissues. Stellate ganglia are of particular interest because the majority of sympathetic neurons innervating the heart reside there. The cardiovascular risk profiles in men and women are different. Transcriptomics provides a powerful tool for identifying genomic changes that contribute to sympathetic dysfunction in disease. Here we compared the transcriptomes of healthy stellate ganglia from adult male and female WKY rats.
Publication Title
No associated publication
Sample Metadata Fields
Sex, Age, Specimen part, Disease, Cell line, Treatment
View Samples- Mus musculus
- 4 Downloadable Samples
Affymetrix Mouse Expression 430A Array (moe430a)
Description
To identify proteins regulated by glucose through changes in their rate of protein synthesis, translational profiling of MIN6 cells acutely incubated at either low or high glucose concentration was performed (i.e. microarray analysis was performed on mRNAs associated with polysomes, as an increase in the association of mRNA with polysomes is indicative of an increase in the rate of initiation step of translation and hence an increase in protein expression) (Johannes et al., 1999; Mikulits et al., 2000).
Publication Title
Distinct glucose-dependent stress responses revealed by translational profiling in pancreatic beta-cells.
Sample Metadata Fields
Specimen part, Cell line, Compound, Time
View Samples- Mus musculus
- 14 Downloadable Samples
- Affymetrix Mouse Gene 1.0 ST Array (mogene10st)
Description
Global gene expression patterns were determined from microarray results on day 1, 3, 5, 7, 10 and 14 during plantaris muscle hypertrophy induced by synergist ablation in young adult mice (5 months).
Publication Title
Time course of gene expression during mouse skeletal muscle hypertrophy.
Sample Metadata Fields
Sex, Age, Specimen part, Treatment, Time
View Samples- Mus musculus
- 7 Downloadable Samples
- Affymetrix Mouse Gene 1.0 ST Array (mogene10st)
Description
Global gene expression patterns were determined from microarray results on day 1, 3, 5, 7, 10 and 14 during plantaris muscle regrowth following two weeks of hind limb suspension in young adult mice (5 months).
Publication Title
No associated publication
Sample Metadata Fields
Age, Specimen part, Time
View Samples
SRP158719- Homo sapiens
- 6 Downloadable Samples
- Illumina HiSeq 3000
Description
The goal of this study was to identify transcriptomic differences in A549 lung cancer cell line following knockout of the RPA1 gene. A549 cells, and many lung tumors, carry constitutive NRF2 activation. Understanding how RPA1 modulates transcription, particularly NRF2-mediated transcription, is relevant for future cancer therapeutics.
Publication Title
No associated publication
Sample Metadata Fields
Sex, Specimen part, Cell line
View Samples- Mus musculus
- 46 Downloadable Samples
- NextSeq 500
Description
The goal of this study was to determine the role of the X-linked epigenetic mediator, O-linked N-acetylglucosamine transferase (OGT) in establishment of trophoblast-specific sex differences in gene expression and to determine if sex differences in OGT and downstream epigenetic modifications contribute to sex differences in hypothalamic gene expression and development.
Publication Title
No associated publication
Sample Metadata Fields
Sex, Specimen part, Cell line, Treatment
View Samples- Homo sapiens
- 16 Downloadable Samples
- Affymetrix Human Genome U133A Array (hgu133a)
Description
Effect of expression of wild type KSHV RTA or the activation domain (aa608-651) deleted version of RTA in 293T cells on gene expression profiling.
Publication Title
No associated publication
Sample Metadata Fields
Cell line, Time
View Samples- Homo sapiens
- 2 Downloadable Samples
- Illumina HiSeq 2000
Description
search differential gene expression with ClC-3 knockdown
Publication Title
No associated publication
Sample Metadata Fields
No sample metadata fields
View Samples- Mus musculus
- 12 Downloadable Samples
- Affymetrix Mouse Genome 430A 2.0 Array (mouse430a2)
Description
To assess a potential role of transcription factor CREM in the long-term detrimental effects of beta1-adrenoceptor overexpression, four mouse lines were generated and studied: wild-type mice (WT), Crem-normal beta1AR-transgenic mice (beta1ARTG), Crem-deficient non-transgenic mice (Crem-/-) and Crem-deficient beta1AR-transgenic mice (beta1ARTG/Crem-/-). We focused on genes up- or down-regulated in transgenic mice due to the lacking of CREM (beta1ARTG/Crem-/- vs. beta1ARTG).
Publication Title
No associated publication
Sample Metadata Fields
Sex, Age, Specimen part
View Samples