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accession-icon GSE24817
Regulation of early folliculogenesis by Sohlh1 and Sohlh2 in mouse ovary
  • organism-icon Mus musculus
  • sample-icon 10 Downloadable Samples
  • Technology Badge IconIllumina MouseWG-6 v2.0 expression beadchip

Description

This SuperSeries is composed of the SubSeries listed below.

Publication Title

No associated publication

Sample Metadata Fields

Specimen part

View Samples
accession-icon GSE21525
Expression data from testis of day-7 Sohlh1 knock-out mice
  • organism-icon Mus musculus
  • sample-icon 12 Downloadable Samples
  • Technology Badge Icon Affymetrix Mouse Genome 430 2.0 Array (mouse4302)

Description

Sohlh1 and Sohlh2 encode a germ cell-specific basic helix-loop-helix transcriptional regulator critical in spermatogonial differentiation. Seven-day-old Sohlh1 or Sohlh2 knockout and wild-type testes were arrayed on the Affy 430 2.0 platform.

Publication Title

No associated publication

Sample Metadata Fields

Specimen part

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accession-icon GSE24816
Transcriptional changes in Sohlh1 knockout and Sohlh2 knockout mouse newborn ovaries
  • organism-icon Mus musculus
  • sample-icon 4 Downloadable Samples
  • Technology Badge IconIllumina MouseWG-6 v2.0 expression beadchip

Description

Sohlh1 and Sohlh2 are germ cell-specific basic helix-loop-helix transcription factors critical in early folliculogenesis. We discovered that Sohlh1 and Sohlh2 knockout females lose oocytes after birth and few remains by postnatal day 14. Here, we show that many genes preferentially expressed in the oocytes are misregulated by Sohlh1 and/or Sohlh2 deficiency.

Publication Title

No associated publication

Sample Metadata Fields

Specimen part

View Samples
accession-icon GSE24815
Transcriptional changes in Sohlh1/Sohlh2 double knockout newborn mouse ovaries
  • organism-icon Mus musculus
  • sample-icon 6 Downloadable Samples
  • Technology Badge IconIllumina MouseWG-6 v2.0 expression beadchip

Description

Sohlh1 and Sohlh2 are germ cell-specific basic helix-loop-helix transcription factors critical in early folliculogenesis. Differential genes expression by both Sohlh1 and Sohlh2 deficiency in mouse newborn ovaries was accessed using microarray. RNA samples from Sohlh1/ Sohlh2 double knockout and wild-type newborn ovaries were arrayed on the Illumina beadchip mouse WG-6 2.0.

Publication Title

No associated publication

Sample Metadata Fields

Specimen part

View Samples
accession-icon GSE39233
Placental PPARg-Regulated Genes
  • organism-icon Mus musculus
  • sample-icon 40 Downloadable Samples
  • Technology Badge Icon Affymetrix Mouse Genome 430 2.0 Array (mouse4302)

Description

Robust identification of placental PPARg target genes via mutliple PPARg-dependence criteria.

Publication Title

Placental PPARγ regulates spatiotemporally diverse genes and a unique metabolic network.

Sample Metadata Fields

Specimen part

View Samples
accession-icon GSE68424
Expression data from glioblastoma stem-like cells
  • organism-icon Homo sapiens
  • sample-icon 18 Downloadable Samples
  • Technology Badge Icon Affymetrix Human Genome U133 Plus 2.0 Array (hgu133plus2)

Description

The objective of this study is to determine how inhibition of microRNA 10b affects gene expression in neurospheres cultures of glioblastoma stem-like cells.

Publication Title

Therapeutic potential of targeting microRNA-10b in established intracranial glioblastoma: first steps toward the clinic.

Sample Metadata Fields

Treatment

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accession-icon GSE7137
Expression data from 18h-fasted WT versus KLF15-null mice: liver and quadriceps skeletal muscle
  • organism-icon Mus musculus
  • sample-icon 16 Downloadable Samples
  • Technology Badge Icon Affymetrix Mouse Genome 430A 2.0 Array (mouse430a2)

Description

We used microarray analysis to identify differences in gene expression levels, in liver and in quadriceps skeletal muscle, between 18h (overnight) fasted WT control and Kruppel-like factor 15 (KLF15)-null mice.

Publication Title

Regulation of gluconeogenesis by Krüppel-like factor 15.

Sample Metadata Fields

No sample metadata fields

View Samples
accession-icon GSE60252
The whole transcriptome expression profiling comparison between the ovarian cancer spheroids and monolayer cells
  • organism-icon Homo sapiens
  • sample-icon 10 Downloadable Samples
  • Technology Badge Icon Affymetrix Human Gene 1.1 ST Array (hugene11st)

Description

To discover the core gene expression features of ovarian cancer spheroids

Publication Title

No associated publication

Sample Metadata Fields

Specimen part, Cell line

View Samples
accession-icon GSE60251
The whole transcriptome expression profiling comparison between the CtBP1 knockdown, CtBP2 knockdown and scramble control in ovarian cancer SKOV3 cells
  • organism-icon Homo sapiens
  • sample-icon 7 Downloadable Samples
  • Technology Badge Icon Affymetrix Human Gene 1.1 ST Array (hugene11st)

Description

To discover the core gene expression features of CtBP1, CtBP2 differently regulated in ovarian cancer SKOV3 cells.

Publication Title

No associated publication

Sample Metadata Fields

Specimen part, Cell line, Treatment

View Samples
accession-icon GSE84539
The whole transcriptome expression profiling comparison between the Pin1 knockIn in Hose cells and Pin1 knockdown in ovarian cancer MCAS and SK-OV-3 cells
  • organism-icon Homo sapiens
  • sample-icon 6 Downloadable Samples
  • Technology Badge Icon Affymetrix Human Gene 1.1 ST Array (hugene11st)

Description

To discover the abnormal regulatory role of Pin1 in the ovarian cancer, The Pin1 full cDNA was knockIn (KI) the normal ovarian epithelium (Hose), and parallelly Pin1 was knockdown in the Ovarian cancer cells MCAS and sk-ov-3, and then compared the expression profiles of them to discovery the key features regulated by Pin1.

Publication Title

No associated publication

Sample Metadata Fields

Cell line

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refine.bio is a repository of uniformly processed and normalized, ready-to-use transcriptome data from publicly available sources. refine.bio is a project of the Childhood Cancer Data Lab (CCDL)

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Developed by the Childhood Cancer Data Lab

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Cite refine.bio

Casey S. Greene, Dongbo Hu, Richard W. W. Jones, Stephanie Liu, David S. Mejia, Rob Patro, Stephen R. Piccolo, Ariel Rodriguez Romero, Hirak Sarkar, Candace L. Savonen, Jaclyn N. Taroni, William E. Vauclain, Deepashree Venkatesh Prasad, Kurt G. Wheeler. refine.bio: a resource of uniformly processed publicly available gene expression datasets.
URL: https://www.refine.bio

Note that the contributor list is in alphabetical order as we prepare a manuscript for submission.

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