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accession-icon GSE85333
Transcriptional effects of anti-inflammatory or anti-depressant drugs on primary human macrophages inflammatory response
  • organism-icon Homo sapiens
  • sample-icon 182 Downloadable Samples
  • Technology Badge Icon Affymetrix Human Gene 2.1 ST Array (hugene21st)

Description

The direct communication between our central nervous and inflammatory signalling systems is a well-recognised, yet poorly understood relationship. To increase our understanding of this relationship, we examined the metabolism of serotonin and its precursor tryptophan in macrophages under inflammatory settings. Both are involved in inflammatory signalling and known to play a major role in mood regulation. Tryptophan depletion by macrophages during inflammation can consequently result in a reduction of serotonin systemically and has been suggested to cause depression. Increased understanding of this system could help overcome the problem of treatment resistant depressed patients. To this end, we treated primary human monocyte derived macrophages with a range of anti-depressant/anti-inflammatory drugs and analysed their transcriptional profile under various inflammatory conditions. In addition to the classic endotoxic driver of inflammation, LPS, we also used IFN which is a constitutive cytokine shown to directly induce depression when administered in high doses. The anti-depressant drugs were not found to have any significant effects on macrophage inflammatory signalling. However, the anti-inflammatories drugs were found to alter components of the serotonin/tryptophan metabolism pathways. This study increases our understanding of the intricacies of immune/mood cross-talk and offers into developing anti-inflammatories as co-treatment for depression.

Publication Title

Effects of anti-inflammatory drugs on the expression of tryptophan-metabolism genes by human macrophages.

Sample Metadata Fields

Sex, Specimen part, Treatment, Subject

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accession-icon GSE108875
Expression data from mouse spleens after experimental stroke (reanalysis of dataset GSE70841 with additional experimental)
  • organism-icon Mus musculus
  • sample-icon 12 Downloadable Samples
  • Technology Badge Icon Affymetrix Mouse Gene 1.0 ST Array (mogene10st)

Description

Infection is a major complication and cause of mortality and morbidity after acute stroke however the mechanisms are poorly understood. After experimental stroke the microarchitecture and cellular composition of the spleen are extensively disrupted resulting in deficits to immune function.

Publication Title

Experimental Stroke Differentially Affects Discrete Subpopulations of Splenic Macrophages.

Sample Metadata Fields

Specimen part, Treatment

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accession-icon GSE78837
The effect of CSF1-Fc treatment in pigs on liver gene expression
  • organism-icon Sus scrofa
  • sample-icon 9 Downloadable Samples
  • Technology Badge Icon Porcine Gene 1.1 ST Array (porgene11st)

Description

The expression was designed to determine whether exposure to CSF1-Fc has any effect on liver-specific gene expression in pigs.

Publication Title

Macrophage colony-stimulating factor (CSF1) controls monocyte production and maturation and the steady-state size of the liver in pigs.

Sample Metadata Fields

Specimen part

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accession-icon GSE52636
The effect of a novel form of macrophage colony-stimulating factor (CSF1-Fc) on gene expression in the liver.
  • organism-icon Mus musculus
  • sample-icon 5 Downloadable Samples
  • Technology Badge Icon Affymetrix Mouse Gene 1.1 ST Array (mogene11st)

Description

Treatment of mice with daily injections of CSF1-Fc produce a 50% increase in the size of the liver within 5 days. There was extensive proliferation of hepatocytes, similar to that seen following partial hepatectomy.

Publication Title

No associated publication

Sample Metadata Fields

Specimen part

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accession-icon GSE53573
The effect of anti-CSF1R treatment on liver gene expression
  • organism-icon Mus musculus
  • sample-icon 5 Downloadable Samples
  • Technology Badge Icon Affymetrix Mouse Gene 1.1 ST Array (mogene11st)

Description

The expression was designed to determine whether prolonged depletion of Kupffer cells has any effect on liver-specific gene expression.

Publication Title

No associated publication

Sample Metadata Fields

Specimen part, Treatment

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accession-icon GSE74079
Expression data from GSS/101LL brain regions
  • organism-icon Mus musculus
  • sample-icon 23 Downloadable Samples
  • Technology Badge Icon Affymetrix Mouse Gene 2.1 ST Array (mogene21st)

Description

Gerstmann Strausller Scheinker (GSS) human prion disease homogenate is i.c. inoculated into mice exhibiting a proline to leucine alteration at codon 101 of the murine prion protein gene (101LL). This results in a disease with an incubation period of approximately 291 days. Normal brain homogenate i.c. inoculated into 101LL mice which are aged matched are used as controls.

Publication Title

Distribution of Misfolded Prion Protein Seeding Activity Alone Does Not Predict Regions of Neurodegeneration.

Sample Metadata Fields

Sex, Specimen part

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accession-icon GSE72039
Defining the microglia response during the time course of chronic neurodegeneration
  • organism-icon Mus musculus
  • sample-icon 16 Downloadable Samples
  • Technology Badge Icon Affymetrix Mouse Gene 1.1 ST Array (mogene11st)

Description

In order to study the microglia contribution in neurodegeneration more specifically we established a mouse model of prion disease in which the 79A murine prion strain was introduced by an intraperitoneal route into BALB/cJFms-EGFP/- mice, which express Enhanced Green Fluorescent Protein (EGFP) under control of the C-fms operon. Samples were taken at time points during disease progression and histological analysis of the brain and transcriptional analysis of isolated microglia was carried out. The analysis of isolated microglia revealed a disease specific, highly pro-inflammatory signature in addition to an up-regulation of genes associated with metabolism, respiratory stress and DNA repair. This study strongly supports the growing recognition of the importance of microglia within the prion disease process and identifies the nature of the response through gene expression analysis of isolated microglia.

Publication Title

Defining the Microglia Response during the Time Course of Chronic Neurodegeneration.

Sample Metadata Fields

Sex, Specimen part

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accession-icon GSE44292
Gene Expression data from mouse bone marrow derived macrophages treated with different inflammatory stimuli
  • organism-icon Mus musculus
  • sample-icon 64 Downloadable Samples
  • Technology Badge Icon Affymetrix Mouse Gene 1.1 ST Array (mogene11st)

Description

The activation profiles of macrophages under different immune and inflammatory conditions have generated great interest. LPS, in particular, is a commonly used in vitro model of infection and inflammation studies in macrophages. We have used gene expression microarrays to define the effects of each of three variables; LPS dose, LPS vs. interferons beta and gamma, and genetic background on the transcriptional response of mouse bone marrow-derived macrophages

Publication Title

Analysis of the transcriptional networks underpinning the activation of murine macrophages by inflammatory mediators.

Sample Metadata Fields

No sample metadata fields

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accession-icon GSE59921
Macrophages from male and female chickens
  • organism-icon Gallus gallus
  • sample-icon 28 Downloadable Samples
  • Technology Badge Icon Affymetrix Chicken Gene 1.0 ST Array (chigene10st), Affymetrix Chicken Genome Array (chicken)

Description

This SuperSeries is composed of the SubSeries listed below.

Publication Title

Cell-autonomous sex differences in gene expression in chicken bone marrow-derived macrophages.

Sample Metadata Fields

Sex, Specimen part

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accession-icon GSE59919
Macrophages from sex-reversed chicken embryos [set1]
  • organism-icon Gallus gallus
  • sample-icon 16 Downloadable Samples
  • Technology Badge Icon Affymetrix Chicken Gene 1.0 ST Array (chigene10st)

Description

To identify markers associated with inherent cellular sex-identity, we analysed cultured macrophages from male and female chick embryos. We found that male and female macrophages respond differently to stimulation by bacterial lipopolysaccharide and that female macrophages constitutively express higher levels of interferon target genes than male macrophages. To determine whether these differences resulted from the actions of gonadal hormones, we induced gonadal sex-reversal to alter the hormonal environment of the developing chick and analysed different tissues and macrophages from male and female embryos.

Publication Title

Cell-autonomous sex differences in gene expression in chicken bone marrow-derived macrophages.

Sample Metadata Fields

Sex, Specimen part

View Samples
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refine.bio is a repository of uniformly processed and normalized, ready-to-use transcriptome data from publicly available sources. refine.bio is a project of the Childhood Cancer Data Lab (CCDL)

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Cite refine.bio

Casey S. Greene, Dongbo Hu, Richard W. W. Jones, Stephanie Liu, David S. Mejia, Rob Patro, Stephen R. Piccolo, Ariel Rodriguez Romero, Hirak Sarkar, Candace L. Savonen, Jaclyn N. Taroni, William E. Vauclain, Deepashree Venkatesh Prasad, Kurt G. Wheeler. refine.bio: a resource of uniformly processed publicly available gene expression datasets.
URL: https://www.refine.bio

Note that the contributor list is in alphabetical order as we prepare a manuscript for submission.

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